منابع مشابه
Topical rapamycin for facial angiofibromas in tuberous sclerosis complex
Facial angiofibromas are a common cutaneous manifestation of tuberous sclerosis complex. Although angiofibromas are usually asymptomatic, they can be highly disfiguring and can have a significant impact on patient quality of life. Treatment for facial angiofibromas is challenging. Recently, topical rapamycin has been proposed as an effective option to treat angiofibromas. Herein is reported a c...
متن کاملTopical Rapamycin Therapy to Alleviate the Cutaneous Manifestations of Tuberous Sclerosis Complex
BACKGROUND AND OBJECTIVES Facial angiofibromas are disfiguring facial lesions, present in up to 80% of patients with tuberous sclerosis complex. Recent elucidation of the complex cell signaling pathways that are disrupted in tuberous sclerosis indicates that rapamycin may be successful in alleviating the appearance of these lesions. The objectives of the current study were to evaluate the safet...
متن کاملSuccessful treatment of subungual fibromas of tuberous sclerosis with topical rapamycin.
atemporal relationshipbetweeninitiationofthedrugandsymptomsof edema (that can vary froma fewmonths to years)may suggest this association.4 The anatomical correlation between lymphedemaandthesiteofprevious surgery (or theareaof the AVFused for hemodialysis)may be explained because trauma to local lymphaticsbyprevioussurgerycancausefailureof lymphangiogenesis as apart ofwoundhealing. Themechanism...
متن کاملTopical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model
BACKGROUND Skin manifestations of Tuberous Sclerosis Complex (TSC) cause significant morbidity. The molecular mechanism underlying TSC is understood and there is evidence that systemic treatment with rapamycin or other mTOR inhibitors may be a useful approach to targeted therapy for the kidney and brain manifestations. Here we investigate topical rapamycin in a mouse model for TSC-related tumor...
متن کاملTopical Rapamycin: An Additional Therapeutic Option for Tufted Angioma in Adults.
Tufted angiomas are relatively rare benign vascular proliferations, which were previously referred to as progressive capilliary hemangiomas or angioblastomas. They appear mainly in patients under 5 years of age, although adult-onset cases have been reported. They present as erythematousviolaceous plaques or nodules affecting the upper trunk and limbs or the neck. Histologic examination is neces...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2010
ISSN: 0003-987X
DOI: 10.1001/archdermatol.2010.125